Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 17/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2520515 | 0.90 | GPR119 (0.66) | GPR119KCNH2 | |
| SCHEMBL12235992 | 0.89 | GPR119 (0.75) | GPR119KCNH2SCN1ASCN8A | |
| SCHEMBL2576914 | 0.87 | GPR119 (0.72) | GPR119KCNH2SCN1ASCN8A | |
| SCHEMBL2450345 | 0.86 | GPR119 (0.68) | GPR119KCNH2EPHX2 | |
| SCHEMBL12213555 | 0.85 | GPR119 (0.69) | GPR119KCNH2SCN1ASCN8A | |
| Hydrochloric Acid SCHEMBL2520461 | 0.84 | GPR119 (0.68) | GPR119KCNH2SCN1ASCN8A | |
| SCHEMBL2458075 | 0.83 | GPR119 (0.49) | GPR119KCNH2EPHX2HRH1CCR3 | |
| SCHEMBL2523758 | 0.82 | GPR119 (1.00) | GPR119KCNH2 | |
| SCHEMBL2551152 | 0.82 | GPR119 (0.70) | GPR119KCNH2 | |
| SCHEMBL12213570 | 0.82 | GPR119 (0.89) | GPR119KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2556069-A1 | PYRIMIDINYLPIPERIDINYLOXYPYRIDINONE ANALOGUES AS GPR119 MODULATORS | Bristol-Myers Squibb Company (US) | 2013-02-13 | — | — | EP | disclosed |
| WO-2011127106-A1 | PYRIMIDINYLPIPERIDINYLOXYPYRIDINONE ANALOGUES AS GPR119 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-10-13 | — | — | WO | disclosed |