Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.52 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2144491 | 0.89 | CYP1A2 (0.61) | SLC6A5HDAC4HDAC6CARM1PRMT6 | |
| SCHEMBL16222287 | 0.87 | CARM1 (0.56) | SLC6A5HDAC4HDAC6CARM1PRMT6 | |
| SCHEMBL25511894 | 0.87 | SLC6A5 (0.54) | SLC6A5HDAC4HDAC6CARM1PRMT6 | |
| SCHEMBL1202785 | 0.87 | SLC6A5 (0.54) | SLC6A5HDAC4HDAC6CARM1PRMT6 | |
| SCHEMBL10195592 | 0.87 | NPC1 (0.69) | SLC6A5HDAC4HDAC6CARM1PRMT6 | |
| SCHEMBL12089912 | 0.86 | LMNA (0.53) | SLC6A5HDAC4HDAC6CARM1PRMT6 | |
| SCHEMBL4749226 | 0.86 | NPC1 (0.67) | SLC6A5HDAC4HDAC6RAB9ANPC1 | |
| SCHEMBL20551505 | 0.86 | NPSR1 (0.54) | SLC6A5HDAC4HDAC6CARM1PRMT6 | |
| SCHEMBL363917 | 0.85 | CARM1 (0.69) | CARM1PRMT6RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL12139819 | 0.84 | MEN1 (0.67) | SLC6A5HDAC4HDAC6CARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023086399-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-05-19 | — | — | WO | disclosed |