SCHEMBL2551253

SCHEMBL2551253

CC(=O)C(Cl)c1ccc(O)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 10/20 0.50
ESR2 Q92731 9/20 0.50
PDCD1 Q15116 1/20 0.46
CD274 Q9NZQ7 1/20 0.46
MAPT P10636 3/20 0.41
CYP3A4 P08684 2/20 0.41
LMNA P02545 2/20 0.41
CYP1A2 P05177 1/20 0.41
PGR P06401 1/20 0.41
CHRM2 P08172 1/20 0.41
ADORA3 P0DMS8 1/20 0.41
AR P10275 1/20 0.41
CYP2D6 P10635 1/20 0.41
CHRM1 P11229 1/20 0.41
CYP2C9 P11712 1/20 0.41
ALOX15 P16050 1/20 0.41
DRD1 P21728 1/20 0.41
TBXA2R P21731 1/20 0.41
PTGS1 P23219 1/20 0.41
SLC6A2 P23975 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3993817 0.82 BRD4 (0.61) CYP3A4LMNACYP1A2ADORA3CYP2D6
SCHEMBL3993198 0.82 SMN1; SMN2 (0.42) LMNATDP1BRD4ALDH1A1MEN1
SCHEMBL4052998 0.80 ACACB (0.40) ESR1ESR2MAPTLMNASLC6A3
SCHEMBL3993015 0.80 CYP1A2 (0.53) CYP1A2CYP2C19BRD4
SCHEMBL1511329 0.80 HDAC3 (0.44) LMNATDP1BRD4ALDH1A1CA1
SCHEMBL3739027 0.79 SRC (0.50) ESR1ESR2PDCD1CD274MAPT
SCHEMBL356020 0.79 LMNA (0.47) MAPTCYP3A4LMNACYP2D6TDP1
SCHEMBL10970026 0.77 ESR1 (0.41) ESR1ESR2PDCD1CD274MAPT
SCHEMBL7431895 0.77 ESR1 (0.41) ESR1ESR2PDCD1CD274MAPT
Methyl Alcohol SCHEMBL28233463 0.77 LMNA (0.46) MAPTCYP3A4LMNACYP2D6ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3036221-A1 SELECTIVE OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE MODULATORS OF NR2B Luc Therapeutics, Inc. (US) 2016-06-29 EP disclosed
WO-2015048507-A1 SELECTIVE OCTAHYDRO-CYCLOPENTA[C] PYRROLE NEGATIVE MODULATORS OF NR2B MNEMOSYNE PHARMACEUTICALS, INC. (US) 2015-04-02 WO disclosed
WO-2011126733-A2 COMBINATION THERAPIES: INHIBITORS OF GABA TRANSAMINASE AND NKCC1 CHILDREN'S MEDICAL CENTER CORPORATION (US) 2011-10-13 WO disclosed
EP-1235776-A1 TRIPHENYLALKENE DERIVATIVES AND THEIR USE AS SELECTIVE ESTROGEN RECEPTOR MODULATORS Hormos Medical Corporation (FI) 2002-09-04 EP disclosed
WO-2001036360-A1 TRIPHENYLALKENE DERIVATIVES AND THEIR USE AS SELECTIVE ESTROGEN RECEPTOR MODULATORS HORMOS MEDICAL CORPORATION (FI) 2001-05-25 WO disclosed