Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | OGA | O60502 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | SMO | Q99835 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17712587 | 0.87 | CHRM4 (0.46) | GPR119NPC1RAB9AKDM4ECHRM4 | |
| SCHEMBL17411217 | 0.86 | GPR119 (0.47) | GPR119DHFRKCNH2NPC1RAB9A | |
| SCHEMBL25193787 | 0.85 | DHFR (0.37) | GPR119DHFRNPC1RAB9AKDM4E | |
| SCHEMBL17712603 | 0.85 | GPR119 (0.49) | GPR119NPC1RAB9AKDM4ECHRM4 | |
| SCHEMBL2556222 | 0.85 | GPR119 (0.46) | GPR119KCNH2CHRM4 | |
| SCHEMBL14623523 | 0.85 | ENPP1 (0.44) | GPR119DHFRKCNH2CHRM4CYP11B2 | |
| SCHEMBL26846402 | 0.80 | GPR119 (0.42) | GPR119DHFRKCNH2KDM4EAOC3 | |
| SCHEMBL17411286 | 0.79 | GPR119 (0.44) | GPR119DHFRKCNH2KDM4EAOC3 | |
| SCHEMBL27363157 | 0.78 | GPR119 (0.39) | GPR119KCNH2 | |
| SCHEMBL12874467 | 0.77 | GPR119 (0.61) | GPR119DHFRKCNH2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023078813-A1 | HETEROBIFUNCTIONAL MOLECULES AS TEAD INHIBITORS | MERCK PATENT GMBH (DE) | 2023-05-11 | — | — | WO | disclosed |