SCHEMBL2551515

SCHEMBL2551515

Cc1ccccc1S(=O)(=O)O.Cc1ccccc1S(=O)(=O)O.c1ccc(C(ON2CCCCC2)c2ccccc2)cc1.c1ccc(C(ON2CCCCC2)c2ccccc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 1/20 0.42
MAPT P10636 1/20 0.38
MEN1 O00255 3/20 0.37
LMNA P02545 3/20 0.37
KMT2A Q03164 3/20 0.37
ALDH1A1 P00352 2/20 0.37
TSHR P16473 3/20 0.37
CYP2D6 P10635 1/20 0.37
PMP22 Q01453 1/20 0.37
SLC6A2 P23975 1/20 0.37
JAK2 O60674 1/20 0.36
CYP3A4 P08684 2/20 0.36
CYP2C9 P11712 2/20 0.36
CYP2C19 P33261 2/20 0.36
MYC P01106 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
CYP1A2 P05177 1/20 0.36
HPGD P15428 1/20 0.36
CNR2 P34972 2/20 0.36
EPHX2 P34913 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2475678 1.00 CHRNA7 (0.42) CHRNA7MAPTMEN1LMNAKMT2A
SCHEMBL2472017 0.83 ALDH1A1 (0.51) MAPTMEN1KMT2AALDH1A1TSHR
SCHEMBL2551518 0.83 ALDH1A1 (0.51) MAPTMEN1KMT2AALDH1A1TSHR
SCHEMBL1802065 0.78 CYP3A4 (0.52) CHRNA7MEN1LMNAKMT2AALDH1A1
Cyclopropane SCHEMBL2101354 0.78 MYC (0.48) MEN1LMNAKMT2AALDH1A1TSHR
SCHEMBL8938184 0.77 CHRNA7 (0.62) CHRNA7MEN1LMNAKMT2ATSHR
SCHEMBL8938188 0.77 CHRNA7 (0.62) CHRNA7MEN1LMNAKMT2ATSHR
Hydrochloric Acid SCHEMBL7654483 0.76 CYP3A4 (0.50) CHRNA7MEN1LMNAKMT2AALDH1A1
SCHEMBL28042294 0.76 CYP2D6 (0.50) CHRNA7LMNATSHRCYP2D6SLC6A2
Carbamic Acid SCHEMBL17460309 0.75 GAA (0.47) MAPTMEN1LMNAKMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011121099-A2 PROCESS FOR THE PREPARATION OF 1-[4-(1,1-DIMETHYLETHYL)PHENYL]-4-[4-(DIPHENYLMETHOXY)-1-PIPERIDINYL]-1-BUTANONE AND ACID ADDITION SALTS THEREOF AREVIPHARMA GMBH (DE) 2011-10-06 WO disclosed