SCHEMBL8938188

SCHEMBL8938188

Cc1ccccc1[C@@H](ON1CCCCC1)c1ccccc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 1/20 0.62
ESR1 P03372 1/20 0.46
TSHR P16473 2/20 0.46
OPRM1 P35372 6/20 0.46
CYP3A4 P08684 6/20 0.46
CYP2D6 P10635 5/20 0.46
CYP2C19 P33261 5/20 0.46
CYP2C9 P11712 4/20 0.46
KCNH2 Q12809 4/20 0.46
SLC22A1 O15245 2/20 0.46
CHRM2 P08172 2/20 0.46
ADRA2A P08913 2/20 0.46
CHRM1 P11229 2/20 0.46
DRD1 P21728 2/20 0.46
SLC6A2 P23975 2/20 0.46
SLC6A4 P31645 2/20 0.46
ADRA1A P35348 2/20 0.46
DRD3 P35462 2/20 0.46
SLC6A3 Q01959 2/20 0.46
SLC22A2 O15244 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8938184 1.00 CHRNA7 (0.62) CHRNA7ESR1TSHROPRM1CYP3A4
SCHEMBL1802065 0.85 CYP3A4 (0.52) CHRNA7TSHROPRM1CYP3A4CYP2D6
Hydrochloric Acid SCHEMBL7654483 0.83 CYP3A4 (0.50) CHRNA7TSHROPRM1CYP3A4CYP2D6
SCHEMBL8938339 0.81 CHRNA7 (0.42) CHRNA7TSHROPRM1CYP3A4CYP2D6
SCHEMBL8938333 0.81 CHRNA7 (0.42) CHRNA7TSHROPRM1CYP3A4CYP2D6
SCHEMBL5765318 0.78 IDO1 (0.56) CHRNA7TSHROPRM1CYP3A4CYP2D6
SCHEMBL2551515 0.77 CHRNA7 (0.42) CHRNA7TSHRCYP3A4CYP2D6CYP2C19
SCHEMBL2475678 0.77 CHRNA7 (0.42) CHRNA7TSHRCYP3A4CYP2D6CYP2C19
Carbamic Acid SCHEMBL17460309 0.76 GAA (0.47) CYP3A4CYP2D6CYP2C19CYP2C9KCNH2
SCHEMBL9353293 0.76 SLC6A3 (0.45) TSHRCYP3A4CYP2D6CYP2C19CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5534626-A SELECTIVE MUSCARINIC RECEPTOR ANTAGONIST INTERMEDIATES PFIZER INC. (US) 1996-07-09 US disclosed
US-5410046-A Selective muscarinic receptor antagonists PFIZER INC. (US) 1995-04-25 US disclosed
US-5231104-A Anticholinergic PFIZER INC. (US) 1993-07-27 US disclosed
EP-0350309-B1 PIPERIDINE DERIVATIVES Pfizer Limited (GB) 1992-11-11 EP disclosed
US-5089505-A Anticholinergic agents PFIZER INC. (US) 1992-02-18 US disclosed
EP-0350309-A1 Piperidine derivatives Pfizer Limited (GB) 1990-01-10 EP disclosed