Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 3/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CCR5 | P51681 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30397855 | 1.00 | MAPK14 (0.42) | MAPK14GRM2PIM1PIM2KDM4E | |
| Trifluoroacetic Acid SCHEMBL25420616 | 0.89 | CCR5 (0.41) | MAPK14GRM2PIM1PIM2ALDH1A1 | |
| SCHEMBL16103438 | 0.80 | MAPK14 (0.49) | MAPK14GRM2PIM1PIM2KDM4E | |
| SCHEMBL30397428 | 0.78 | MAPK14 (0.40) | MAPK14GRM2ALDH1A1KMT2A | |
| SCHEMBL25418562 | 0.78 | MAPK14 (0.40) | MAPK14GRM2ALDH1A1KMT2A | |
| SCHEMBL25418416 | 0.76 | KDM4E (0.37) | PIM1PIM2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL30397943 | 0.76 | MAPK13 (0.41) | GRM2 | |
| SCHEMBL30397669 | 0.76 | MAPK13 (0.41) | GRM2 | |
| SCHEMBL5662280 | 0.74 | KDM4E (0.43) | MAPK14GRM2PIM1PIM2KDM4E | |
| SCHEMBL30397072 | 0.74 | PTPN1 (0.40) | PIM1PIM2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |