SCHEMBL2551646

SCHEMBL2551646

O=P(O)(O)CN(CCN(Cc1ccccc1O)CP(=O)(O)O)Cc1ccccc1O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.42
HTR1A P08908 1/20 0.41
HSPA5 P11021 1/20 0.41
AKR1B1 P15121 1/20 0.40
TSHR P16473 2/20 0.38
MEN1 O00255 1/20 0.38
RECQL P46063 1/20 0.38
KMT2A Q03164 1/20 0.38
CYP2D6 P10635 1/20 0.37
HIF1A Q16665 1/20 0.37
HTT P42858 2/20 0.36
ALDH1A1 P00352 1/20 0.36
HPGD P15428 1/20 0.36
TAAR1 Q96RJ0 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
IDO1 P14902 1/20 0.35
CA12 O43570 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24673207 0.83 TSHR (0.41) HTR1ATSHRCYP2D6CYP1A2CYP2C19
SCHEMBL9395374 0.81 HSPA5 (0.54) HTR1AHSPA5AKR1B1TSHRMEN1
SCHEMBL15693017 0.79 GAA (0.35) GAAHTR1AHSPA5AKR1B1TSHR
SCHEMBL24673193 0.79 APP (0.39) HTR1ATSHRIDO1
SCHEMBL12191321 0.79 GABRA1 (0.36)
SCHEMBL12214441 0.79 HTR1A (0.42) GAAHTR1ATSHRMEN1KMT2A
SCHEMBL12191339 0.77 GAA (0.33) GAAHTR1AHSPA5AKR1B1TSHR
SCHEMBL15283002 0.77 HSPA5 (0.59) HTR1AHSPA5AKR1B1TSHRMEN1
SCHEMBL20180914 0.76 HSPA5 (0.48) HTR1AHSPA5AKR1B1TSHRMEN1
SCHEMBL12281557 0.75 TSHR (0.36) GAATSHRMEN1KMT2ACYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2552493-B1 Hydroxylated phosphorylated contrast enhancement agents GEN ELECTRIC (US) 2015-01-14 EP disclosed
US-8765977-B2 Hydroxylated contrast enhancement agents and imaging method GENERAL ELECTRIC COMPANY (US) 2014-07-01 US disclosed
US-8722020-B2 Hydroxylated contrast enhancement agents GENERAL ELECTRIC COMPANY (US) 2014-05-13 US disclosed
EP-2552493-A1 HYDROXYLATED PHOSPHORYLATED CONTRAST ENHANCEMENT AGENTS General Electric Company (US) 2013-02-06 EP disclosed
WO-2011121002-A1 HYDROXYLATED PHOSPHORYLATED CONTRAST ENHANCEMENT AGENTS GENERAL ELECTRIC COMPANY (US) 2011-10-06 WO disclosed