Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | BRD2 | P25440 | 1/20 | 0.46 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | IDH1 | O75874 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23833645 | 0.85 | CYP3A4 (0.49) | CYP3A4CYP2C19ALDH1A1TP53TDP1 | |
| SCHEMBL23833599 | 0.82 | ALDH1A1 (0.48) | CYP3A4CYP2C19ALDH1A1TP53TDP1 | |
| SCHEMBL25522424 | 0.81 | CYP3A4 (0.46) | CYP3A4CYP2C19ALDH1A1TP53TDP1 | |
| SCHEMBL4365231 | 0.80 | CYP3A4 (0.68) | CYP3A4CYP2C19ALDH1A1MAPTCA12 | |
| SCHEMBL633994 | 0.74 | ALDH1A1 (0.68) | CYP3A4CYP2C19ALDH1A1TP53TDP1 | |
| SCHEMBL16455751 | 0.73 | ALDH1A1 (0.45) | ALDH1A1MAPTBRD4BRD2BRD3 | |
| SCHEMBL3842083 | 0.73 | KMT2A (0.56) | CYP3A4CYP2C19ALDH1A1TP53TDP1 | |
| SCHEMBL7822430 | 0.73 | KMT2A (0.54) | CYP3A4CYP2C19ALDH1A1TP53TDP1 | |
| SCHEMBL16139760 | 0.73 | ALDH1A1 (0.56) | CYP3A4ALDH1A1MAPTCA12CA1 | |
| SCHEMBL30925472 | 0.73 | SLC40A1 (0.69) | ALDH1A1TDP1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159489-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND USE | AKEBIA THERAPEUTICS, INC. (US) | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159489-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND USE | HIF1AN, EGLN3, PHF20 | CYP3A4 3938/4885CYP2C19 3644/4885ALDH1A1 963/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.