Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 13/20 | 0.57 |
| ▸ | IL1B | P01584 | 7/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30517832 | 1.00 | NLRP3 (0.57) | NLRP3IL1BKCNH2CAMK2DADORA2A | |
| SCHEMBL25303253 | 0.87 | NLRP3 (0.55) | NLRP3IL1BKCNH2TNF | |
| SCHEMBL25254731 | 0.87 | NLRP3 (0.55) | NLRP3IL1BKCNH2TNF | |
| SCHEMBL29270330 | 0.86 | NLRP3 (0.57) | NLRP3IL1BKCNH2CAMK2DADORA2A | |
| SCHEMBL25300069 | 0.86 | NLRP3 (0.51) | NLRP3IL1BKCNH2CAMK2DTNF | |
| SCHEMBL25300070 | 0.86 | NLRP3 (0.51) | NLRP3IL1BKCNH2CAMK2DTNF | |
| SCHEMBL31021469 | 0.85 | NLRP3 (0.48) | NLRP3IL1BKCNH2CAMK2DADORA2A | |
| SCHEMBL31367803 | 0.85 | NLRP3 (0.57) | NLRP3IL1BKCNH2CAMK2DADORA2A | |
| SCHEMBL29030489 | 0.85 | IL1B (0.48) | NLRP3IL1BKCNH2TNF | |
| SCHEMBL25304051 | 0.85 | IL1B (0.48) | NLRP3IL1BKCNH2TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118265701-A | Pyridazine derivatives as inhibitors of NLRP3 | 豪夫迈·罗氏有限公司 | 2024-06-28 | — | — | CN | disclosed |
| WO-2023088987-A1 | PYRIDAZINE DERIVATIVES AS INHIBITORS OF NLRP3 | F. HOFFMANN-LA ROCHE AG (CH) | 2023-05-25 | — | — | WO | disclosed |