SCHEMBL25519684

SCHEMBL25519684

CCCCc1ccc2cc(F)ccc2n1

nearest known ligand 0.50

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PDE10A Q9Y233 6/20 0.50
BACE1 P56817 1/20 0.47
HDAC1 Q13547 1/20 0.45
HDAC2 Q92769 1/20 0.45
KCNH2 Q12809 1/20 0.41
TLR8 Q9NR97 1/20 0.40
TSHR P16473 1/20 0.38
AGTR1 P30556 1/20 0.38
AGTR2 P50052 1/20 0.38
PDE4A P27815 1/20 0.37
PDE4B Q07343 1/20 0.37
CYSLTR2 Q9NS75 2/20 0.37
CYSLTR1 Q9Y271 2/20 0.37
GRM1 Q13255 1/20 0.37
LTB4R Q15722 1/20 0.37
GPBAR1 Q8TDU6 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15482291 0.88 PDE10A (0.47) PDE10AKCNH2AGTR1AGTR2CYSLTR2
SCHEMBL7838005 0.82 BACE1 (0.53) PDE10ABACE1HDAC1HDAC2TSHR
SCHEMBL9936785 0.80 KDM4E (0.51) KCNH2TLR8TSHRGRM1LTB4R
SCHEMBL14911775 0.79 PDE10A (0.50) PDE10ABACE1HDAC1HDAC2TSHR
SCHEMBL27754053 0.79 BACE1 (0.50) PDE10ABACE1HDAC1HDAC2TSHR
SCHEMBL14352128 0.79 BACE1 (0.55) PDE10ABACE1HDAC1HDAC2PDE4A
SCHEMBL127792 0.79 BACE1 (0.53) PDE10ABACE1HDAC1HDAC2TSHR
SCHEMBL20515371 0.79 TERT (0.50) KCNH2TLR8GRM1LTB4R
SCHEMBL28176588 0.76 TLR7 (0.41) BACE1KCNH2TLR8
SCHEMBL29846618 0.75 LMNA (0.50) KCNH2TLR8LTB4RGPBAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023086428-A2 NOVEL MODULATORS OF THE ARYL HYDROCARBON RECEPTOR AND METHODS OF USE THEREOF ALLIANTHERA (SUZHOU) BIOPHARMACEUTICAL CO., LTD. (CN) 2023-05-19 WO disclosed