⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23765253 | 0.86 | ALDH1A1 (0.33) | — | |
| SCHEMBL11932071 | 0.86 | ALDH1A1 (0.33) | — | |
| SCHEMBL25474620 | 0.86 | EPHX1 (0.31) | — | |
| SCHEMBL23765298 | 0.86 | ALDH1A1 (0.33) | — | |
| SCHEMBL26151498 | 0.82 | ALDH1A1 (0.32) | — | |
| SCHEMBL26151551 | 0.80 | ALDH1A1 (0.30) | — | |
| SCHEMBL26153213 | 0.77 | — | — | |
| SCHEMBL1091004 | 0.75 | APLNR (0.33) | — | |
| SCHEMBL23338007 | 0.73 | ALDH1A1 (0.31) | — | |
| SCHEMBL28567554 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159466-A1 | INHIBITORS OF HIF-2ALPHA AND METHODS OF USE THEREOF | ARCUS BIOSCIENCES, INC. | 2023-05-25 | — | — | US | disclosed |
| US-20230159466-A1 | INHIBITORS OF HIF-2ALPHA AND METHODS OF USE THEREOF | ARCUS BIOSCIENCES, INC. | 2023-05-25 | — | — | US | disclosed |
| US-20230150972-A1 | PYRIDINYL DERIVATIVES AS SODIUM CHANNEL ACTIVATORS | XENON PHARMACEUTICALS INC. (CA) | 2023-05-18 | — | — | US | disclosed |
| US-20230150972-A1 | PYRIDINYL DERIVATIVES AS SODIUM CHANNEL ACTIVATORS | XENON PHARMACEUTICALS INC. (CA) | 2023-05-18 | — | — | US | disclosed |