Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 10/20 | 0.34 |
| ▸ | JAK1 | P23458 | 10/20 | 0.34 |
| ▸ | TYK2 | P29597 | 10/20 | 0.34 |
| ▸ | KDR | P35968 | 10/20 | 0.34 |
| ▸ | JAK3 | P52333 | 10/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 10/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | USP7 | Q93009 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | TEK | Q02763 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25520074 | 0.79 | RPS6KA3 (0.36) | RPS6KA3DHFRJAK2JAK1TYK2 | |
| SCHEMBL25522341 | 0.78 | RPS6KA3 (0.36) | RPS6KA3DHFRJAK2JAK1TYK2 | |
| SCHEMBL25522055 | 0.76 | VRK1 (0.35) | RPS6KA3DHFRJAK2JAK1TYK2 | |
| SCHEMBL25522349 | 0.72 | ESR1 (0.36) | RPS6KA3BRAFNPC1RAB9A | |
| SCHEMBL25522353 | 0.70 | TLR8 (0.38) | — | |
| SCHEMBL31538918 | 0.69 | JAK2 (0.33) | JAK2JAK1TYK2KDRJAK3 | |
| SCHEMBL27033288 | 0.69 | JAK2 (0.33) | JAK2JAK1TYK2KDRJAK3 | |
| SCHEMBL30726167 | 0.69 | JAK2 (0.33) | JAK2JAK1TYK2KDRJAK3 | |
| SCHEMBL25522334 | 0.68 | KDM4E (0.35) | JAK2JAK1TYK2KDRJAK3 | |
| SCHEMBL25522347 | 0.68 | KDM4E (0.48) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023086428-A2 | NOVEL MODULATORS OF THE ARYL HYDROCARBON RECEPTOR AND METHODS OF USE THEREOF | ALLIANTHERA (SUZHOU) BIOPHARMACEUTICAL CO., LTD. (CN) | 2023-05-19 | — | — | WO | disclosed |