Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | ULK1 | O75385 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 3/20 | 0.39 |
| ▸ | CCNH | P51946 | 3/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CCNK | O75909 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25522696 | 0.84 | ULK1 (0.55) | CDK2KDRCDK1ULK1CDK7 | |
| SCHEMBL25523794 | 0.80 | KDR (0.47) | CDK2KDRCDK1ULK1PTK2 | |
| SCHEMBL30397492 | 0.76 | ULK1 (0.49) | CDK2KDRCDK1ULK1CCNT1 | |
| SCHEMBL31006885 | 0.76 | CCNK (0.56) | CDK2CDK7CCNHMNAT1CCNT1 | |
| SCHEMBL25531573 | 0.76 | CCNK (0.56) | CDK2CDK7CCNHMNAT1CCNT1 | |
| SCHEMBL25531402 | 0.76 | ULK1 (0.49) | CDK2KDRCDK1ULK1CCNT1 | |
| SCHEMBL25518045 | 0.74 | KDR (0.41) | CDK2KDRCDK1PTK2AURKA | |
| SCHEMBL22998319 | 0.74 | ULK1 (0.44) | CDK2KDRCDK1ULK1PTK2 | |
| SCHEMBL30397617 | 0.74 | ULK1 (0.46) | CDK2KDRCDK1ULK1CDK7 | |
| SCHEMBL25516689 | 0.74 | ULK1 (0.46) | CDK2KDRCDK1ULK1CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |