Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 8/20 | 0.55 |
| ▸ | CDK2 | P24941 | 6/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.42 |
| ▸ | CTSC | P53634 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.39 |
| ▸ | CCNK | O75909 | 4/20 | 0.39 |
| ▸ | CDK9 | P50750 | 4/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 4/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CCNH | P51946 | 1/20 | 0.38 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25531573 | 0.87 | CCNK (0.56) | CDK2CCNE1CCNT1CCNKCDK9 | |
| SCHEMBL30397492 | 0.87 | ULK1 (0.49) | ULK1CDK2KDRCDK1CCNE1 | |
| SCHEMBL31006885 | 0.87 | CCNK (0.56) | CDK2CCNE1CCNT1CCNKCDK9 | |
| SCHEMBL25531402 | 0.87 | ULK1 (0.49) | ULK1CDK2KDRCDK1CCNE1 | |
| SCHEMBL22998319 | 0.84 | ULK1 (0.44) | ULK1CDK2KDRCDK1PAK1 | |
| SCHEMBL30397617 | 0.84 | ULK1 (0.46) | ULK1CDK2KDRCDK1CCNE1 | |
| SCHEMBL25516689 | 0.84 | ULK1 (0.46) | ULK1CDK2KDRCDK1CCNE1 | |
| SCHEMBL25523172 | 0.84 | CDK2 (0.47) | ULK1CDK2KDRCDK1CCNE1 | |
| SCHEMBL28486909 | 0.82 | ULK1 (0.42) | ULK1CDK2KDRCDK1PAK1 | |
| SCHEMBL30397019 | 0.82 | ULK1 (0.43) | ULK1CDK2KDRCDK1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |