Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27906114 | 0.90 | AAK1 (0.40) | AAK1LMNAL3MBTL1USP30PTK2 | |
| SCHEMBL17572193 | 0.85 | AAK1 (0.39) | AAK1USP30PTK2ALDH1A1SSTR4 | |
| SCHEMBL27906122 | 0.84 | AAK1 (0.41) | AAK1LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL4015276 | 0.82 | SIRT2 (0.43) | AAK1LMNAL3MBTL1USP30ALDH1A1 | |
| SCHEMBL3635744 | 0.81 | SSTR4 (0.38) | AAK1LMNAMAPTALDH1A1SSTR4 | |
| SCHEMBL31255675 | 0.81 | KDM4E (0.35) | AAK1L3MBTL1PTK2MAPTALDH1A1 | |
| SCHEMBL2553564 | 0.80 | PTK2 (0.44) | LMNAL3MBTL1PTK2MAPTALDH1A1 | |
| SCHEMBL3987633 | 0.80 | USP30 (0.41) | AAK1LMNAL3MBTL1USP30PTK2 | |
| SCHEMBL2552511 | 0.77 | TSHR (0.41) | AAK1LMNAL3MBTL1MAPTALDH1A1 | |
| SCHEMBL2946714 | 0.76 | SSTR4 (0.37) | AAK1USP30MAPTALDH1A1SSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552206-A1 | TRYCYCLIC COMPOUNDS AND PBK INHIBITORS CONTAINING THE SAME | OncoTherapy Science, Inc. (JP) | 2013-02-06 | — | — | EP | disclosed |
| WO-2011123419-A1 | TRYCYCLIC COMPOUNDS AND PBK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2011-10-06 | — | — | WO | disclosed |