Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 2/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19086382 | 0.81 | PTK2 (0.43) | PTK2DGAT1TMEM97SIGMAR1ALDH1A1 | |
| SCHEMBL2552329 | 0.80 | AAK1 (0.42) | PTK2DGAT1FPR2ALDH1A1MAPT | |
| SCHEMBL17420936 | 0.78 | SIRT2 (0.48) | PTK2DGAT1TMEM97SIGMAR1ALDH1A1 | |
| SCHEMBL17078095 | 0.76 | TSHR (0.48) | SIGMAR1ALDH1A1MAPTLMNAGLA | |
| SCHEMBL6832796 | 0.75 | ALDH1A1 (0.44) | DGAT1ALDH1A1MAPTSIRT2THRB | |
| SCHEMBL3991292 | 0.75 | DGAT1 (0.42) | PTK2DGAT1FPR2TMEM97SIGMAR1 | |
| SCHEMBL57513 | 0.74 | DGAT1 (0.41) | PTK2DGAT1FPR2TMEM97SIGMAR1 | |
| SCHEMBL3892297 | 0.74 | DPP4 (0.35) | PTK2DGAT1ALDH1A1SIRT2LMNA | |
| SCHEMBL3892298 | 0.74 | DPP4 (0.35) | PTK2DGAT1ALDH1A1SIRT2LMNA | |
| SCHEMBL27906114 | 0.72 | AAK1 (0.40) | PTK2DGAT1FPR2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552206-A1 | TRYCYCLIC COMPOUNDS AND PBK INHIBITORS CONTAINING THE SAME | OncoTherapy Science, Inc. (JP) | 2013-02-06 | — | — | EP | disclosed |
| WO-2011123419-A1 | TRYCYCLIC COMPOUNDS AND PBK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2011-10-06 | — | — | WO | disclosed |