Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19003377 | 0.86 | AAK1 (0.41) | AAK1NCEH1ALDH1A1L3MBTL1NPC1 | |
| SCHEMBL30175909 | 0.86 | AAK1 (0.41) | AAK1NCEH1ALDH1A1L3MBTL1NPC1 | |
| SCHEMBL20671184 | 0.84 | AAK1 (0.40) | AAK1NCEH1ALDH1A1L3MBTL1NPC1 | |
| SCHEMBL22439649 | 0.84 | PDK2 (0.46) | SSTR4PDK2ABL1 | |
| SCHEMBL30116140 | 0.84 | AAK1 (0.40) | AAK1NCEH1ALDH1A1L3MBTL1NPC1 | |
| SCHEMBL17427750 | 0.83 | SIRT2 (0.45) | SIRT2DGAT1NCEH1ALDH1A1L3MBTL1 | |
| SCHEMBL3987633 | 0.83 | USP30 (0.41) | SIRT2AAK1USP30DGAT1NCEH1 | |
| SCHEMBL18157853 | 0.82 | ABL1 (0.37) | AAK1PDK2ABL1 | |
| SCHEMBL30370098 | 0.82 | ABL1 (0.37) | AAK1PDK2ABL1 | |
| SCHEMBL27634058 | 0.82 | AAK1 (0.49) | AAK1NCEH1ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4743453-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | Pretzel Therapeutics, Inc. (US) | 2026-05-20 | — | — | EP | disclosed |
| WO-2025015178-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | PRETZEL THERAPEUTICS, INC. (US) | 2025-01-16 | — | — | WO | disclosed |
| CN-118702683-A | Phenyl ethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-09-27 | — | — | CN | disclosed |
| US-12024503-B2 | Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof | LYNK PHARMACEUTICALS CO. LTD. (CN) | 2024-07-02 | — | — | US | disclosed |
| US-12024503-B2 | Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof | LYNK PHARMACEUTICALS CO. LTD. (CN) | 2024-07-02 | — | — | US | disclosed |
| US-12024503-B2 | Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof | LYNK PHARMACEUTICALS CO. LTD. (CN) | 2024-07-02 | — | — | US | disclosed |
| CN-113993861-B | Phenyl ethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-05-14 | — | — | CN | disclosed |
| US-20240083882-A1 | BENZETHERS AND ANILINES OF PYRAZOLYL-AMINO-PYRIMIDINYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF | LYNK PHARMACEUTICALS CO. LTD. (CN) | 2024-03-14 | — | — | US | disclosed |
| WO-2020206588-A1 | BENZETHERS AND ANILINES OF PYRAZOLYL-AMINO-PYRIMIDINYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF | LYNK PHARMACEUTICALS CO., LTD. (CN) | 2020-10-15 | — | — | WO | disclosed |
| WO-2020207414-A1 | BENZETHERS AND ANILINES OF PYRAZOLYL-AMINO-PYRIMIDINYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF | LYNK PHARMACEUTICALS CO. LTD. (CN) | 2020-10-15 | — | — | WO | disclosed |
| CN-100348609-C | Glucocorticoid receptor ligands for the treatment of metabolic disorders | KAROBIO AB (SE) | 2007-11-14 | — | — | CN | disclosed |
| US-20070027117-A1 | Novel glucocorticoid receptor ligands for the treatment of metabolic disorders | BISHOP RICHARD D | 2007-02-01 | — | — | US | disclosed |
| US-20070027117-A1 | Novel glucocorticoid receptor ligands for the treatment of metabolic disorders | BISHOP RICHARD D | 2007-02-01 | — | — | US | disclosed |
| US-20070027117-A1 | Novel glucocorticoid receptor ligands for the treatment of metabolic disorders | BISHOP RICHARD D | 2007-02-01 | — | — | US | disclosed |
| US-7141559-B2 | Glucocorticoid receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2006-11-28 | — | — | US | disclosed |
| EP-1551860-B1 | GLUCOCORTICOID RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KAROBIO AB (SE) | 2006-11-22 | — | — | EP | disclosed |
| CN-1662549-A | Glucocorticoid receptor ligands for the treatment of metabolic disorders | KAROBIO AB (SE) | 2005-08-31 | — | — | CN | disclosed |
| EP-1551860-A1 | GLUCOCORTICOID RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2005-07-13 | — | — | EP | disclosed |
| US-20040235810-A1 | Novel glucocorticoid receptor ligands for the treatment of metabolic disorders | ABBOTT LABORATORIES | 2004-11-25 | — | — | US | disclosed |
| WO-2004000869-A1 | GLUCOCORTICOID RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2003-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12024503-B2 | Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof | JAK3, JAK1, JAK2 | SIRT2 2361/4885AAK1 510/4885USP30 2195/4885 |
| US-20070027117-A1 | Novel glucocorticoid receptor ligands for the treatment of metabolic disorders | GPR119, NR3C1, INSR | SIRT2 2921/4885AAK1 1603/4885USP30 2263/4885 |
| US-20040235810-A1 | Novel glucocorticoid receptor ligands for the treatment of metabolic disorders | GPR119, NR3C1, INSR | SIRT2 2921/4885AAK1 1603/4885USP30 2263/4885 |
| US-20240083882-A1 | BENZETHERS AND ANILINES OF PYRAZOLYL-AMINO-PYRIMIDINYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF | JAK3, JAK1, JAK2 | SIRT2 2297/4885AAK1 504/4885USP30 2210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.