Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25523616 | 0.85 | SSTR4 (0.42) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL6018000 | 0.83 | HDAC3 (0.43) | HDAC1HDAC3HDAC2NCOR2SSTR4 | |
| SCHEMBL25523653 | 0.82 | HDAC1 (0.36) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL6017972 | 0.81 | HDAC3 (0.41) | HDAC1HDAC3HDAC2NCOR2TRPM8 | |
| SCHEMBL31419052 | 0.81 | HDAC1 (0.36) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL23774902 | 0.79 | HDAC1 (0.35) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL23774900 | 0.78 | SSTR4 (0.42) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL4932966 | 0.74 | HDAC3 (0.53) | HDAC1HDAC3HDAC2NCOR2TRPM8 | |
| SCHEMBL6018387 | 0.73 | CYP1A2 (0.40) | HDAC1HDAC3HDAC2NCOR2SSTR4 | |
| SCHEMBL6738132 | 0.73 | LDHA (0.41) | HDAC1HDAC3HDAC2NCOR2TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159510-A1 | NOVEL PRMT5 INHIBITORS | AMGEN INC. (US) | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159510-A1 | NOVEL PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT3 | HDAC1 35/4885HDAC8 145/4885HDAC6 244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.