Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | PRF1 | P14222 | 12/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21403857 | 0.79 | LRRK2 (0.45) | LRRK2GABRA1PRF1MKNK1 | |
| SCHEMBL30397487 | 0.79 | LRRK2 (0.45) | LRRK2GABRA1PRF1MKNK1 | |
| SCHEMBL29084843 | 0.79 | LRRK2 (0.40) | LRRK2GABRA1PRF1MKNK1 | |
| SCHEMBL25289133 | 0.79 | LRRK2 (0.40) | LRRK2GABRA1PRF1MKNK1 | |
| SCHEMBL25421259 | 0.79 | LRRK2 (0.40) | LRRK2GABRA1PRF1MKNK1 | |
| SCHEMBL15571453 | 0.77 | PRF1 (0.46) | PRF1 | |
| SCHEMBL29084811 | 0.77 | GABRA1 (0.47) | LRRK2GABRA1PRF1MKNK1 | |
| SCHEMBL25512529 | 0.77 | LRRK2 (0.38) | LRRK2GABRA1PRF1MKNK1 | |
| SCHEMBL23349324 | 0.74 | GABRA1 (0.39) | LRRK2GABRA1MKNK1 | |
| SCHEMBL15571500 | 0.74 | PRF1 (0.56) | PRF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |