Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.39 |
| ▸ | PRF1 | P14222 | 8/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21403857 | 1.00 | LRRK2 (0.45) | LRRK2GABRA1PRF1GABRG2GABRB3 | |
| SCHEMBL25289133 | 0.79 | LRRK2 (0.40) | LRRK2GABRA1PRF1MKNK1 | |
| SCHEMBL25523969 | 0.79 | LRRK2 (0.40) | LRRK2GABRA1PRF1MKNK1 | |
| SCHEMBL29084843 | 0.79 | LRRK2 (0.40) | LRRK2GABRA1PRF1GABRG2GABRB3 | |
| SCHEMBL25512529 | 0.77 | LRRK2 (0.38) | LRRK2GABRA1PRF1GABRG2GABRB3 | |
| SCHEMBL29084811 | 0.77 | GABRA1 (0.47) | LRRK2GABRA1PRF1GABRG2GABRB3 | |
| SCHEMBL30592769 | 0.76 | GABRA1 (0.44) | GABRA1PRF1 | |
| SCHEMBL21403886 | 0.76 | GABRA1 (0.44) | GABRA1PRF1 | |
| SCHEMBL22226945 | 0.76 | MAPK1 (0.44) | GABRA1 | |
| SCHEMBL29144098 | 0.76 | CHRNB2 (0.32) | LRRK2GABRA1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119431345-A | Compound for regulating 15-PGDH activity and preparation method thereof | 赛诺哈勃药业（成都）有限公司 | 2025-02-14 | — | — | CN | disclosed |
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023088425-A1 | 15-PGDH INHIBITOR AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2023-05-25 | — | — | WO | disclosed |
| CN-116135856-A | 15-PGDH inhibitor and application thereof | 武汉人福创新药物研发中心有限公司 | 2023-05-19 | — | — | CN | disclosed |