Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.58 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2553103 | 0.87 | MET (0.69) | METCYP3A4CASP3SENP8SENP7 | |
| SCHEMBL2554270 | 0.86 | MET (0.63) | METABL1CYP3A4CASP3SENP8 | |
| SCHEMBL2551917 | 0.83 | MET (0.66) | METCYP3A4NPC1 | |
| SCHEMBL2576776 | 0.77 | MET (0.54) | METCYP3A4 | |
| SCHEMBL2555041 | 0.76 | MET (0.58) | METCYP3A4 | |
| SCHEMBL3721556 | 0.75 | MET (0.69) | METCYP3A4KDM4E | |
| SCHEMBL2763443 | 0.74 | MET (1.00) | METABL1CYP3A4 | |
| SCHEMBL2550322 | 0.73 | MET (0.57) | METCYP3A4 | |
| SCHEMBL2552274 | 0.73 | MET (0.49) | METCYP3A4KDM4E | |
| SCHEMBL2549710 | 0.73 | MET (0.73) | METABL1CYP3A4CASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011121223-A1 | 6-(ALKYL- OR CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLE DERIVATIVES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS MET INHIBITORS | SANOFI-AVENTIS (FR) | 2011-10-06 | — | — | WO | disclosed |