Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2551917 | 0.96 | MET (0.66) | METCYP3A4 | |
| SCHEMBL2555041 | 0.89 | MET (0.58) | METCYP3A4 | |
| SCHEMBL2552455 | 0.87 | MET (0.58) | METCYP3A4CASP3SENP8SENP7 | |
| SCHEMBL2549710 | 0.86 | MET (0.73) | METCYP3A4CASP3SENP8SENP7 | |
| SCHEMBL2555024 | 0.85 | MET (0.74) | METCYP3A4CASP3SENP8SENP7 | |
| SCHEMBL3719030 | 0.83 | MET (0.70) | METCYP3A4CASP3SENP8SENP7 | |
| SCHEMBL2800569 | 0.83 | MET (0.70) | METCYP3A4CASP3SENP8SENP7 | |
| SCHEMBL2554477 | 0.82 | MET (0.62) | METCYP3A4 | |
| SCHEMBL3722129 | 0.81 | MET (0.70) | METCYP3A4CASP3SENP8SENP7 | |
| SCHEMBL3726507 | 0.81 | MET (0.67) | METCYP3A4CASP3SENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011121223-A1 | 6-(ALKYL- OR CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLE DERIVATIVES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS MET INHIBITORS | SANOFI-AVENTIS (FR) | 2011-10-06 | — | — | WO | disclosed |