SCHEMBL25526501

SCHEMBL25526501

O=C(O)CC1c2cc(F)cc(F)c2OCC12CC2

nearest known ligand 0.35

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 6/20 0.32
HSD11B1 P28845 2/20 0.32
FFAR1 O14842 3/20 0.31
ALDH1A1 P00352 1/20 0.30
GAA P10253 1/20 0.30
LTB4R Q15722 1/20 0.30
LTB4R2 Q9NPC1 1/20 0.30
PPARG P37231 1/20 0.30
PPARD Q03181 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25528923 0.84 EIF4A3 (0.32) FFAR4
SCHEMBL25859676 0.79 AKR1B1 (0.32) FFAR4HSD11B1FFAR1ALDH1A1GAA
SCHEMBL25529237 0.79 PPARG (0.32) FFAR4PPARGPPARD
SCHEMBL25528305 0.78 AKR1B1 (0.36) FFAR4FFAR1LTB4RLTB4R2PPARG
SCHEMBL25860608 0.76 AKR1B1 (0.42) HSD11B1FFAR1LTB4RLTB4R2PPARG
SCHEMBL22992539 0.70 PSEN1 (0.38) FFAR4HSD11B1
SCHEMBL22992538 0.70 PSEN1 (0.38) FFAR4HSD11B1
SCHEMBL25854089 0.70
SCHEMBL22992537 0.70 PSEN1 (0.38) FFAR4HSD11B1
SCHEMBL25527859 0.67 HSD11B1 (0.37) FFAR4HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230227437-A1 IMMUNOMODULATOR HITGEN INC (CN) 2023-07-20 US disclosed
EP-4183783-A1 IMMUNOMODULATOR Hitgen Inc. (CN) 2023-05-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230227437-A1 IMMUNOMODULATOR IL17A, IL2, IL2RA FFAR4 2419/4885HSD11B1 284/4885FFAR1 1858/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.