Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 12/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.41 |
| ▸ | GLS | O94925 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25529693 | 0.90 | ROCK2 (0.51) | PARP1ROCK2ROCK1 | |
| SCHEMBL25528196 | 0.84 | ROCK2 (0.43) | PARP1ROCK2ROCK1GLSGSK3B | |
| SCHEMBL25528343 | 0.84 | PARP1 (0.43) | PARP1ROCK2CDK1CCNB1CCNA2 | |
| SCHEMBL25528200 | 0.80 | ROCK2 (0.40) | PARP1ROCK2ROCK1GSK3BMAP4K4 | |
| SCHEMBL25531233 | 0.79 | IRAK4 (0.42) | PARP1ROCK2ROCK1GSK3B | |
| SCHEMBL25528771 | 0.79 | ROCK2 (0.42) | PARP1ROCK2ROCK1 | |
| SCHEMBL25528201 | 0.78 | ROCK2 (0.39) | PARP1ROCK2ROCK1GSK3BMAP4K4 | |
| SCHEMBL25528339 | 0.78 | PARP1 (0.41) | PARP1ROCK2ROCK1GLSMAP4K4 | |
| SCHEMBL25529692 | 0.78 | ROCK2 (0.52) | ROCK2ROCK1 | |
| SCHEMBL25528185 | 0.77 | ROCK2 (0.43) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023093787-A1 | BENZODIAZEPINE COMPOUND AND APPLICATION THEREOF AS RHO KINASE INHIBITOR | 成都奥睿药业有限公司 | 2023-06-01 | — | — | WO | disclosed |