Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25205512 | 0.87 | TYK2 (0.38) | TYK2L3MBTL1P2RX7ALDH1A1CYP1A2 | |
| SCHEMBL30174234 | 0.87 | TYK2 (0.38) | TYK2L3MBTL1P2RX7ALDH1A1CYP1A2 | |
| SCHEMBL25533553 | 0.85 | KDM4E (0.42) | TYK2L3MBTL1P2RX7ALDH1A1RAB9A | |
| SCHEMBL25529152 | 0.77 | TYK2 (0.35) | TYK2NPC1ALDH1A1RAB9ARXFP1 | |
| SCHEMBL25529134 | 0.76 | L3MBTL1 (0.38) | L3MBTL1NPC1ALDH1A1RAB9ARXFP1 | |
| SCHEMBL25207165 | 0.71 | TYK2 (0.37) | TYK2P2RX7AHRHRH3 | |
| SCHEMBL25208803 | 0.70 | TYK2 (0.47) | TYK2L3MBTL1P2RX7ALDH1A1CYP1A2 | |
| SCHEMBL30367326 | 0.70 | TYK2 (0.47) | TYK2L3MBTL1P2RX7ALDH1A1CYP1A2 | |
| SCHEMBL30174271 | 0.69 | TYK2 (0.56) | TYK2P2RX7ALDH1A1AHR | |
| SCHEMBL30367362 | 0.69 | TYK2 (0.46) | TYK2ALDH1A1RAB9ACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230151003-A1 | COMPOUNDS AND METHODS OF USE | EXELIXIS INC (US) | 2023-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230151003-A1 | COMPOUNDS AND METHODS OF USE | PRKACB, PRKACA, PRKX | TYK2 391/4885L3MBTL1 3091/4885P2RX7 2206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.