Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.47 |
| ▸ | SLC22A12 | Q96S37 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.42 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7911305 | 0.90 | PTGS2 (0.56) | PTGS2KDM4EGAAMAPTMEN1 | |
| SCHEMBL509798 | 0.88 | AKR1B1 (0.54) | PTGS2KDM4EGAAMAPTMEN1 | |
| SCHEMBL20045094 | 0.87 | PTGS2 (0.56) | PTGS2KDM4EGAAMAPTMEN1 | |
| SCHEMBL1004574 | 0.86 | KDM4E (0.58) | PTGS2KDM4EGAAMAPTMEN1 | |
| SCHEMBL14395077 | 0.83 | PTGS2 (0.42) | PTGS2KDM4EGAAMAPTMEN1 | |
| SCHEMBL1827626 | 0.83 | PTGS2 (0.42) | PTGS2SLC22A12POLBGABRA1GABRB2 | |
| SCHEMBL1133207 | 0.82 | KDM4E (0.46) | PTGS2KDM4EGAAMAPTMEN1 | |
| SCHEMBL17058860 | 0.81 | PTGS2 (0.41) | PTGS2MEN1KMT2ASLC22A12POLB | |
| SCHEMBL29101379 | 0.79 | AKR1B1 (0.46) | PTGS2KDM4EGAAMAPTMEN1 | |
| SCHEMBL8189339 | 0.79 | AKR1B1 (0.46) | PTGS2KDM4EGAAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3625222-B1 | PHENYL DERIVATIVES AS PGE2 RECEPTOR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2021-07-21 | — | — | EP | disclosed |
| EP-3625228-B1 | PYRIMIDINE DERIVATIVES AS PGE2 RECEPTOR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2021-07-07 | — | — | EP | disclosed |
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |