Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.38 |
| ▸ | WNT1 | P04628 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | WNT3A | P56704 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2553465 | 0.89 | MET (0.53) | METCYP3A4 | |
| SCHEMBL2576776 | 0.84 | MET (0.54) | METCYP3A4 | |
| SCHEMBL2550322 | 0.83 | MET (0.57) | METCYP3A4 | |
| SCHEMBL2552274 | 0.83 | MET (0.49) | METCYP3A4 | |
| SCHEMBL2554270 | 0.81 | MET (0.63) | METCYP3A4 | |
| SCHEMBL3720726 | 0.75 | MET (0.49) | METCYP3A4 | |
| SCHEMBL3722617 | 0.74 | MET (0.50) | METCYP3A4 | |
| SCHEMBL2553888 | 0.74 | MET (0.57) | METCYP3A4 | |
| SCHEMBL2576078 | 0.73 | MET (0.59) | METCYP3A4 | |
| SCHEMBL2552619 | 0.73 | MET (0.54) | METCYP3A4DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011121223-A1 | 6-(ALKYL- OR CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLE DERIVATIVES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS MET INHIBITORS | SANOFI-AVENTIS (FR) | 2011-10-06 | — | — | WO | claimed |
| WO-2011121223-A1 | 6-(ALKYL- OR CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLE DERIVATIVES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS MET INHIBITORS | SANOFI-AVENTIS (FR) | 2011-10-06 | — | — | WO | disclosed |