Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.35 |
| ▸ | KDM4D | Q6B0I6 | 4/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.34 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25526013 | 0.90 | BTK (0.42) | BTKDRD2KMT2AL3MBTL1JAK3 | |
| SCHEMBL25517516 | 0.84 | DRD2 (0.43) | BTKDRD2KMT2AL3MBTL1JAK3 | |
| SCHEMBL25538909 | 0.84 | IRAK4 (0.41) | BTKDRD2KMT2AL3MBTL1JAK3 | |
| SCHEMBL25538557 | 0.78 | BTK (0.42) | BTKKMT2AL3MBTL1JAK3KDM4D | |
| SCHEMBL30397549 | 0.77 | BTK (0.42) | BTKDRD2KMT2AL3MBTL1JAK3 | |
| SCHEMBL30397860 | 0.77 | BTK (0.42) | BTKDRD2KMT2AL3MBTL1JAK3 | |
| SCHEMBL25525059 | 0.77 | BTK (0.41) | BTKDRD2KMT2AL3MBTL1JAK3 | |
| SCHEMBL30397932 | 0.76 | BTK (0.43) | BTKDRD2KMT2AL3MBTL1JAK3 | |
| SCHEMBL30397246 | 0.76 | BTK (0.41) | BTKKMT2AL3MBTL1JAK3KDM4D | |
| SCHEMBL25525623 | 0.76 | BTK (0.43) | BTKKMT2AL3MBTL1JAK3KDM4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |