Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 13/20 | 0.41 |
| ▸ | TNF | P01375 | 7/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25538793 | 0.86 | BTK (0.43) | IRAK4BTKJAK3KMT2AL3MBTL1 | |
| SCHEMBL25533370 | 0.84 | BTK (0.41) | IRAK4BTKJAK3DRD2KMT2A | |
| SCHEMBL25517516 | 0.84 | DRD2 (0.43) | IRAK4BTKJAK3DRD2KMT2A | |
| SCHEMBL25526013 | 0.83 | BTK (0.42) | IRAK4BTKJAK3DRD2KMT2A | |
| SCHEMBL30397355 | 0.80 | KMT2A (0.46) | BTKJAK3DRD2KMT2AL3MBTL1 | |
| SCHEMBL25525059 | 0.77 | BTK (0.41) | BTKJAK3DRD2KMT2AL3MBTL1 | |
| SCHEMBL30397932 | 0.76 | BTK (0.43) | BTKJAK3DRD2KMT2AL3MBTL1 | |
| SCHEMBL25540719 | 0.76 | KMT2A (0.46) | BTKJAK3DRD2KMT2AL3MBTL1 | |
| SCHEMBL25525043 | 0.76 | SUV39H2 (0.44) | BTKJAK3DRD2KMT2AL3MBTL1 | |
| SCHEMBL30397494 | 0.76 | BTK (0.39) | BTKJAK3DRD2KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |