Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 3/20 | 0.56 |
| ▸ | CA2 | P00918 | 3/20 | 0.56 |
| ▸ | CA12 | O43570 | 2/20 | 0.56 |
| ▸ | CA7 | P43166 | 2/20 | 0.56 |
| ▸ | CA9 | Q16790 | 2/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.56 |
| ▸ | ESR1 | P03372 | 1/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.56 |
| ▸ | STS | P08842 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1790586 | 0.86 | CA1 (0.59) | LMNACYP1A2CYP3A4MAOACA1 | |
| SCHEMBL3485540 | 0.85 | CA12 (0.58) | LMNACYP1A2CYP3A4MAOACA1 | |
| SCHEMBL7744097 | 0.84 | LMNA (0.53) | LMNACYP1A2CYP3A4MAOACA1 | |
| SCHEMBL26325379 | 0.84 | LMNA (0.60) | LMNACYP1A2CYP3A4MAOACA1 | |
| SCHEMBL5708223 | 0.83 | LMNA (0.62) | LMNACYP1A2CYP3A4MAOACA1 | |
| SCHEMBL19331900 | 0.83 | LMNA (0.62) | LMNACYP1A2CYP3A4MAOACA1 | |
| SCHEMBL4446216 | 0.83 | MAPT (0.59) | CA1CA2CA12CA7CA9 | |
| SCHEMBL27870324 | 0.83 | TAAR1 (0.47) | LMNACYP1A2CYP3A4MAOACA1 | |
| SCHEMBL3642172 | 0.83 | LMNA (0.54) | LMNACYP1A2CYP3A4MAOACA1 | |
| SCHEMBL571045 | 0.82 | CA12 (0.63) | LMNACYP1A2CYP3A4MAOACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426244-B1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS INC (US) | 2023-06-07 | — | — | EP | disclosed |