Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.37 |
| ▸ | SKP1 | P63208 | 1/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25516501 | 0.86 | BTK (0.47) | BTKKMT2AL3MBTL1JAK1JAK2 | |
| SCHEMBL25517157 | 0.81 | KMT2A (0.61) | BTKKMT2AL3MBTL1JAK1JAK2 | |
| SCHEMBL25534135 | 0.81 | BTK (0.51) | BTKKMT2AL3MBTL1JAK1JAK2 | |
| SCHEMBL25534167 | 0.80 | BTK (0.50) | BTKKMT2AL3MBTL1JAK1JAK2 | |
| SCHEMBL25534848 | 0.78 | BTK (0.48) | BTKKMT2AL3MBTL1JAK1JAK2 | |
| SCHEMBL30397552 | 0.77 | BTK (0.43) | BTKKMT2AL3MBTL1JAK1JAK2 | |
| SCHEMBL25534630 | 0.77 | BTK (0.47) | BTKKMT2AL3MBTL1JAK1JAK2 | |
| SCHEMBL30397355 | 0.77 | KMT2A (0.46) | BTKKMT2AL3MBTL1JAK1JAK2 | |
| SCHEMBL25540719 | 0.77 | KMT2A (0.46) | BTKKMT2AL3MBTL1JAK1JAK2 | |
| SCHEMBL30397798 | 0.76 | BTK (0.40) | BTKKMT2AL3MBTL1JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |