Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 5/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25540719 | 0.84 | KMT2A (0.46) | KMT2AL3MBTL1BTKKDM1AMAOB | |
| SCHEMBL25517566 | 0.83 | KMT2A (0.49) | KMT2AL3MBTL1BTKKDM1AMAOB | |
| SCHEMBL30397552 | 0.82 | BTK (0.43) | KMT2AL3MBTL1BTKKDM1AMAOB | |
| SCHEMBL25538793 | 0.82 | BTK (0.43) | KMT2AL3MBTL1BTKKDM1AMAOB | |
| SCHEMBL30397856 | 0.81 | KMT2A (0.45) | KMT2AL3MBTL1BTKKDM1AMAOB | |
| SCHEMBL25538909 | 0.80 | IRAK4 (0.41) | KMT2AL3MBTL1BTKDRD2JAK3 | |
| SCHEMBL25530705 | 0.78 | CYP3A4 (0.30) | — | |
| SCHEMBL25523570 | 0.77 | BTK (0.44) | KMT2AL3MBTL1BTKKDM1AMAOB | |
| SCHEMBL25533067 | 0.77 | BTK (0.44) | KMT2AL3MBTL1BTKKDM1AMAOB | |
| SCHEMBL25534104 | 0.77 | BTK (0.50) | KMT2AL3MBTL1BTKKDM1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |