Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25534135 | 0.85 | BTK (0.51) | BTKKMT2AL3MBTL1CA1CA2 | |
| SCHEMBL25534167 | 0.84 | BTK (0.50) | BTKKMT2AL3MBTL1CA1CA2 | |
| SCHEMBL25534630 | 0.82 | BTK (0.47) | BTKKMT2AL3MBTL1CA1CA2 | |
| SCHEMBL25534104 | 0.78 | BTK (0.50) | BTKPOLBKMT2AL3MBTL1CA1 | |
| SCHEMBL25516521 | 0.75 | BTK (0.47) | BTKPOLBKMT2AL3MBTL1CA1 | |
| SCHEMBL25517482 | 0.75 | BTK (0.47) | BTKKMT2AL3MBTL1CA1CA2 | |
| SCHEMBL25533067 | 0.74 | BTK (0.44) | BTKKMT2AL3MBTL1CA1CA2 | |
| SCHEMBL25517566 | 0.74 | KMT2A (0.49) | BTKPOLBKMT2AL3MBTL1JAK2 | |
| SCHEMBL30397552 | 0.74 | BTK (0.43) | BTKKMT2AL3MBTL1CA1CA2 | |
| SCHEMBL25516501 | 0.73 | BTK (0.47) | BTKKMT2AL3MBTL1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |