Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | APEX1 | P27695 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.33 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25235077 | 0.86 | POLB (0.41) | POLBAPEX1TDP1L3MBTL1KDM4E | |
| SCHEMBL1137068 | 0.84 | KDM4E (0.54) | POLBAPEX1TDP1L3MBTL1KDM4E | |
| SCHEMBL10517562 | 0.80 | ESR1 (0.46) | POLBAPEX1TDP1L3MBTL1KDM4E | |
| SCHEMBL26601309 | 0.79 | NR4A1 (0.49) | POLBAPEX1TDP1L3MBTL1KDM4E | |
| SCHEMBL26601369 | 0.79 | AKR1C3 (0.49) | POLBAPEX1TDP1L3MBTL1KDM4E | |
| SCHEMBL25233228 | 0.79 | RIPK3 (0.45) | POLBAPEX1TDP1L3MBTL1KDM4E | |
| SCHEMBL4433936 | 0.79 | CDC25B (0.50) | POLBAPEX1TDP1L3MBTL1KDM4E | |
| SCHEMBL362582 | 0.79 | LMNA (0.57) | POLBAPEX1TDP1L3MBTL1KDM4E | |
| SCHEMBL26601277 | 0.76 | KDM4E (0.47) | POLBAPEX1TDP1L3MBTL1KDM4E | |
| SCHEMBL4812121 | 0.73 | ALDH1A1 (0.43) | POLBAPEX1TDP1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230151003-A1 | COMPOUNDS AND METHODS OF USE | EXELIXIS INC (US) | 2023-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230151003-A1 | COMPOUNDS AND METHODS OF USE | PRKACB, PRKACA, PRKX | POLB 1012/4885APEX1 2031/4885TDP1 612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.