SCHEMBL2553500

SCHEMBL2553500

O=Cc1cccc(-c2cnc(Cl)c(C(=O)O)c2)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRIM24 O15164 1/20 0.54
TRIM33 Q9UPN9 1/20 0.54
CDK8 P49336 1/20 0.49
DYRK1A Q13627 2/20 0.46
DYRK2 Q92630 2/20 0.46
DYRK1B Q9Y463 2/20 0.46
DYRK3 O43781 1/20 0.46
CCNT1 O60563 1/20 0.46
CDK9 P50750 1/20 0.46
CDK5 Q00535 1/20 0.46
CDK5R1 Q15078 1/20 0.46
AXL P30530 1/20 0.45
UNG P13051 1/20 0.45
LMNA P02545 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
MAP4K4 O95819 2/20 0.40
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA9 Q16790 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2559514 0.86 TRIM24 (0.57) TRIM24TRIM33CDK8DYRK1ADYRK2
SCHEMBL2557326 0.85 LMNA (0.44) TRIM24TRIM33AXLUNGLMNA
SCHEMBL2563039 0.84 TRIM24 (0.52) TRIM24TRIM33CDK8DYRK1ADYRK2
SCHEMBL10561251 0.83 AKR1C2 (0.53) LMNASMN1; SMN2MAP4K4AKR1C2AKR1C1
SCHEMBL2558026 0.81 TRIM24 (0.49) TRIM24TRIM33CDK8DYRK1ADYRK2
SCHEMBL31312290 0.81 TRIM24 (0.62) TRIM24TRIM33UNGSMN1; SMN2CA12
SCHEMBL2560594 0.81 TRIM24 (0.62) TRIM24TRIM33UNGSMN1; SMN2CA12
SCHEMBL15653224 0.78 SMN1; SMN2 (0.47) TRIM24TRIM33UNGLMNASMN1; SMN2
SCHEMBL2554748 0.78 TRIM24 (0.48) TRIM24TRIM33CDK8DYRK1ADYRK2
SCHEMBL2554092 0.78 TRIM24 (0.62) TRIM24TRIM33UNGSMN1; SMN2CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed