SCHEMBL2553585

SCHEMBL2553585

OB(O)c1ccc(COc2cccc(F)c2F)cc1

nearest known ligand 0.49

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LIPE Q05469 1/20 0.45
HTR1A P08908 2/20 0.41
SLC6A2 P23975 2/20 0.41
SLC6A4 P31645 2/20 0.41
SLC6A3 Q01959 2/20 0.41
F11 P03951 1/20 0.41
NPC1 O15118 3/20 0.40
MRGPRX4 Q96LA9 2/20 0.40
MEN1 O00255 3/20 0.40
KMT2A Q03164 3/20 0.40
RAB9A P51151 2/20 0.40
KDM1A O60341 2/20 0.40
ENPP2 Q13822 3/20 0.38
LPL P06858 1/20 0.38
LIPG Q9Y5X9 1/20 0.38
KDM4E B2RXH2 1/20 0.38
CASP3 P42574 1/20 0.38
SENP7 Q9BQF6 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15332594 0.85 ENPP2 (0.48) LIPEHTR1ASLC6A2SLC6A4SLC6A3
SCHEMBL9706382 0.80 MAPT (0.58) LIPEHTR1ASLC6A2SLC6A4SLC6A3
SCHEMBL30080427 0.80 MAPT (0.58) LIPEHTR1ASLC6A2SLC6A4SLC6A3
SCHEMBL10091216 0.79 MAPT (0.49) HTR1ASLC6A2SLC6A4SLC6A3NPC1
SCHEMBL16692010 0.79 NPC1 (0.51) HTR1ASLC6A2SLC6A4SLC6A3NPC1
SCHEMBL2554083 0.78 NR3C2 (0.44) LIPEHTR1ASLC6A2SLC6A4SLC6A3
SCHEMBL18285478 0.76 CA1 (0.52) HTR1ASLC6A2SLC6A4SLC6A3ENPP2
SCHEMBL17433357 0.75 TDP1 (0.45) HTR1ASLC6A2SLC6A4SLC6A3NPC1
SCHEMBL28187930 0.75 MAOA (0.52) HTR1ASLC6A2SLC6A4SLC6A3NPC1
SCHEMBL30518379 0.75 MAPT (0.58) LIPENPC1MRGPRX4MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed