Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 6/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.37 |
| ▸ | STAT6 | P42226 | 3/20 | 0.36 |
| ▸ | CLK1 | P49759 | 2/20 | 0.36 |
| ▸ | STAT5A | P42229 | 1/20 | 0.36 |
| ▸ | STAT5B | P51692 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPRC | P08575 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25546953 | 0.93 | PTPN2 (0.50) | PTPN2HDAC1STAT6CLK1STAT5A | |
| SCHEMBL23866870 | 0.92 | PTPN2 (0.41) | PTPN2BCL2L1ALDH1A1HDAC1STAT6 | |
| SCHEMBL26251267 | 0.82 | PTPN2 (0.42) | PTPN2BCL2L1HDAC1STAT6CLK1 | |
| SCHEMBL26299272 | 0.80 | TBXAS1 (0.41) | PTPN2BCL2L1ALDH1A1HDAC1CLK1 | |
| SCHEMBL22479179 | 0.79 | PTPN2 (0.37) | PTPN2ALDH1A1HDAC1STAT6CLK1 | |
| SCHEMBL25262323 | 0.78 | ALDH1A1 (0.37) | PTPN2BCL2L1ALDH1A1HDAC1CLK1 | |
| SCHEMBL30527732 | 0.78 | ALDH1A1 (0.37) | PTPN2BCL2L1ALDH1A1HDAC1CLK1 | |
| SCHEMBL25305445 | 0.78 | ALDH1A1 (0.37) | PTPN2BCL2L1ALDH1A1HDAC1CLK1 | |
| SCHEMBL25305442 | 0.78 | ALDH1A1 (0.37) | PTPN2BCL2L1ALDH1A1HDAC1CLK1 | |
| SCHEMBL31611102 | 0.78 | ALDH1A1 (0.37) | PTPN2BCL2L1ALDH1A1HDAC1CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159573-A1 | SMALL MOLECULE STAT PROTEIN DEGRADERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159573-A1 | SMALL MOLECULE STAT PROTEIN DEGRADERS | STAT1, STAT3, STAT5A | PTPN2 418/4885BCL2L1 2051/4885ALDH1A1 2054/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.