Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17156122 | 0.81 | ALOX15 (0.59) | ALDH1A1MEN1KMT2AHTTNPC1 | |
| SCHEMBL5880760 | 0.76 | RAB9A (0.53) | POLBALDH1A1MAPTGAANPC1 | |
| SCHEMBL4575441 | 0.76 | HPGD (0.55) | POLBALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL10938284 | 0.75 | SMN1; SMN2 (0.55) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL653251 | 0.75 | ALOX15 (0.65) | POLBALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL1722181 | 0.73 | NPC1 (0.54) | ALDH1A1MEN1KMT2AHTTNPC1 | |
| SCHEMBL4948738 | 0.73 | POLB (0.54) | POLBALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL2531951 | 0.73 | POLB (0.54) | POLBALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL13382671 | 0.73 | POLB (0.54) | POLBALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL1432953 | 0.73 | POLB (0.54) | POLBALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558094-A1 | PYRIDONE DERIVATIVES | Merck Sharp & Dohme Corp. (US) | 2013-02-20 | — | — | EP | disclosed |
| US-20120316200-A1 | PYRIDONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-12-13 | — | — | US | disclosed |
| US-20120316200-A1 | PYRIDONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-12-13 | — | — | US | disclosed |
| US-20120316200-A1 | PYRIDONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-12-13 | — | — | US | disclosed |
| WO-2011130086-A1 | PYRIDONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-10-20 | — | — | WO | disclosed |
| WO-2011127643-A1 | PYRIDONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-10-20 | — | — | WO | disclosed |
| WO-2011130086-A1 | PYRIDONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-10-20 | — | — | WO | disclosed |
| WO-2011127643-A1 | PYRIDONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120316200-A1 | PYRIDONE DERIVATIVES | MC1R, MC5R, MCHR1 | POLB 2874/4885ALDH1A1 1125/4885MEN1 1405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.