SCHEMBL2554196

SCHEMBL2554196

Nc1ncc(C=O)cc1-c1ccccc1F

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
USP7 Q93009 1/20 0.41
ATR Q13535 1/20 0.39
MAP4K4 O95819 2/20 0.38
NPC1 O15118 1/20 0.38
ALDH1A1 P00352 3/20 0.38
KDM4E B2RXH2 2/20 0.38
GLA P06280 1/20 0.38
GAA P10253 1/20 0.38
HPGD P15428 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
ALOX5AP P20292 3/20 0.38
FEN1 P39748 3/20 0.38
MPL P40238 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
CASP3 P42574 1/20 0.35
SENP8 Q96LD8 1/20 0.35
SENP7 Q9BQF6 1/20 0.35
SENP6 Q9GZR1 1/20 0.35
DRD2 P14416 1/20 0.35
DRD1 P21728 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2554450 0.88 PTPN11 (0.39) ATRNPC1
SCHEMBL15333189 0.81 ATR (0.42) ATRALDH1A1KDM4EALOX5APFEN1
SCHEMBL29951522 0.79 MAP4K4 (0.51) USP7MAP4K4
SCHEMBL15330978 0.77 ALOX5AP (0.43) ALOX5APFEN1DRD2DRD1DRD4
SCHEMBL2561948 0.76 MAP4K4 (0.54) USP7MAP4K4ALDH1A1KDM4EL3MBTL1
SCHEMBL2558901 0.76 CHEK2 (0.53) USP7ATRMAP4K4
SCHEMBL26916367 0.76 KMT2A (0.46) USP7ATRMAP4K4NPC1ALDH1A1
SCHEMBL29857589 0.76 KMT2A (0.46) USP7ATRMAP4K4NPC1ALDH1A1
SCHEMBL29951470 0.76 PIK3CA (0.33) MAP4K4ALDH1A1L3MBTL1
SCHEMBL25428723 0.75 NPC1 (0.40) NPC1ALDH1A1KDM4EL3MBTL1CASP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed