SCHEMBL25545181

SCHEMBL25545181

CCSc1nccn1-c1ccc(NC)cc1

nearest known ligand 0.51

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TP53 P04637 2/20 0.51
THRB P10828 1/20 0.51
CYP1A2 P05177 4/20 0.49
CYP3A4 P08684 4/20 0.49
CYP2D6 P10635 4/20 0.49
CYP2C9 P11712 4/20 0.49
CYP2C19 P33261 4/20 0.49
L3MBTL1 Q9Y468 3/20 0.49
ALOX15B O15296 1/20 0.49
GAA P10253 1/20 0.49
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
MAPT P10636 2/20 0.44
POLB P06746 1/20 0.44
TSHR P16473 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25545138 0.83 TP53 (0.57) TP53THRBCYP1A2CYP3A4CYP2D6
SCHEMBL11386185 0.81 CYP1A2 (0.51) TP53THRBCYP1A2CYP3A4CYP2D6
Hydrochloric Acid SCHEMBL11377342 0.81 POLB (0.54) TP53THRBCYP1A2CYP3A4CYP2D6
Hydrochloric Acid SCHEMBL11376841 0.78 CYP1A2 (0.57) TP53THRBCYP1A2CYP3A4CYP2D6
SCHEMBL10899860 0.76 PDE4A (0.46) TP53THRBCYP1A2CYP3A4CYP2D6
SCHEMBL21646520 0.74 ALDH1A1 (0.57) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL11381134 0.70 CYP1A2 (0.52) TP53THRBCYP1A2CYP3A4CYP2D6
SCHEMBL24045320 0.67 POLB (0.49) TP53THRBCYP1A2CYP3A4CYP2D6
SCHEMBL25545216 0.67 MAPT (0.46) TP53CYP1A2CYP3A4CYP2D6CYP2C9
Hydrochloric Acid SCHEMBL11385536 0.67 CYP1A2 (0.55) TP53THRBCYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023081967-A1 COMPOUNDS AND USES THEREFOR THE UNIVERSITY OF WESTERN AUSTRALIA (AU) 2023-05-19 WO disclosed