Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 5/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 5/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.46 |
| ▸ | SPR | P35270 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DNM1L | O00429 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12467241 | 0.91 | HTR2B (0.42) | PIM1PIM3PIM2SPRHTR2B | |
| SCHEMBL996815 | 0.85 | LDHA (0.51) | PIM1PIM3PIM2LDHAALDH1A1 | |
| SCHEMBL417132 | 0.84 | AOC3 (0.47) | PIM1PIM3PIM2SPRHTR2B | |
| SCHEMBL11912169 | 0.83 | PIM1 (0.44) | PIM1PIM3PIM2LDHANPC1 | |
| SCHEMBL1247127 | 0.83 | LDHA (0.49) | PIM1PIM3PIM2LDHAALDH1A1 | |
| SCHEMBL19929685 | 0.82 | PIM1 (0.43) | PIM1PIM3PIM2LDHANPC1 | |
| SCHEMBL20850964 | 0.82 | PIM1 (0.43) | PIM1PIM3PIM2LDHANPC1 | |
| SCHEMBL20031628 | 0.82 | PIM1 (0.43) | PIM1PIM3PIM2LDHANPC1 | |
| SCHEMBL19929684 | 0.82 | PIM1 (0.43) | PIM1PIM3PIM2LDHANPC1 | |
| SCHEMBL18601672 | 0.82 | PIM1 (0.43) | PIM1PIM3PIM2LDHANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2556066-A1 | PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE | F. Hoffmann-La Roche AG (CH) | 2013-02-13 | — | — | EP | disclosed |
| WO-2011124580-A1 | PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-10-13 | — | — | WO | disclosed |