Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.47 |
| ▸ | BAZ2A | Q9UIF9 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 5/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | SPR | P35270 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylene Chloride SCHEMBL27709754 | 0.94 | AOC3 (0.46) | AOC3BAZ2AGSK3BDYRK1AHPGDS | |
| SCHEMBL12467241 | 0.89 | HTR2B (0.42) | AOC3SPRHTR2BPIM1PIM3 | |
| SCHEMBL491211 | 0.86 | HPGDS (0.46) | AOC3BAZ2AGSK3BDYRK1AHPGDS | |
| SCHEMBL13997973 | 0.84 | BAZ2A (0.52) | AOC3BAZ2AGSK3BDYRK1AHPGDS | |
| SCHEMBL28264041 | 0.84 | PIM1 (0.46) | CDC7SPRHTR2BMEN1KMT2A | |
| SCHEMBL2554941 | 0.84 | PIM1 (0.46) | CDC7SPRHTR2BMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL2516985 | 0.83 | BAZ2A (0.51) | AOC3BAZ2AGSK3BDYRK1AHPGDS | |
| SCHEMBL26979851 | 0.81 | HTR2B (0.38) | SPRHTR2BPIM1PIM3PIM2 | |
| SCHEMBL14379269 | 0.81 | PLAT (0.45) | AOC3BAZ2AGSK3BDYRK1AHPGDS | |
| SCHEMBL31705780 | 0.81 | PLAT (0.45) | AOC3BAZ2AGSK3BDYRK1AHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111196805-A | Synthesis method and application of piperidyl thiazole formamide compound | 曲阜德禄生物科技有限公司 | 2020-05-26 | — | — | CN | claimed |
| CN-111196805-A | Synthesis method and application of piperidyl thiazole formamide compound | 曲阜德禄生物科技有限公司 | 2020-05-26 | — | — | CN | disclosed |
| CN-111196805-A | Synthesis method and application of piperidyl thiazole formamide compound | 曲阜德禄生物科技有限公司 | 2020-05-26 | — | — | CN | disclosed |
| CN-105744833-B | Use the fluidized bed prilling of Prohexadione calcium and the aqueous solution of mineral sulfates | 巴斯夫欧洲公司 | 2018-07-24 | — | — | CN | disclosed |
| CN-103561570-B | Alkoxylated polyalkyleneimine as agrochemical formula dispersant | 巴斯夫欧洲公司 | 2016-10-05 | — | — | CN | disclosed |
| CN-104378980-B | Comprise the emulsifiable concentrate of pesticide, amide, carbonic ester and hydrocarbon | 巴斯夫欧洲公司 | 2016-08-24 | — | — | CN | disclosed |
| CN-102596910-A | Androgen receptor modulating compounds | ORION CORP | 2012-07-18 | — | — | CN | disclosed |
| US-8106048-B2 | protozoal infestations in humans and animals, by bacteria, viruses or proteinaceous agents; neurological diseases or disorders; ischemia and/or reperfusion injury; 4-(4-Ethoxycarbonyl-4,5-dihydro-thiazol-2-yl)-piperidine-1-carboxylic acid t-butyl ester | 4SC AG (DE) | 2012-01-31 | — | — | US | disclosed |
| US-20120022068-A1 | NOVEL HETEROCYCLIC NF-kB INHIBITORS | 4SC AG (DE) | 2012-01-26 | — | — | US | disclosed |
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |
| WO-2007104557-A2 | NOVEL HETEROCYCLIC NF-KB INHIBITORS | 4SC AG (DE) | 2007-09-20 | — | — | WO | disclosed |
| WO-2007104558-A1 | THIAZOLES AS NF-KB INHIBITORS (PROTEASOME INHIBITORS) | 4SC AG (DE) | 2007-09-20 | — | — | WO | disclosed |
| US-20070219190-A1 | Heterocyclic NF-kB Inhibitors | 4SC AG (DE) | 2007-09-20 | — | — | US | disclosed |
| EP-1834954-A1 | Thiazoles as NF-kB Inhibitors (proteasome inhibitors) | 4SC AG (DE) | 2007-09-19 | — | — | EP | disclosed |
| EP-1797084-A1 | NOVEL HETEROCYCLIC NF-kB INHIBITORS | 4SC AG (DE) | 2007-06-20 | — | — | EP | disclosed |
| WO-2007016979-A2 | NOVEL HETEROCYCLIC NF-κB INHIBITORS | 4SC AG (DE) | 2007-02-15 | — | — | WO | disclosed |
| US-20060247253-A1 | Novel heterocyclic NF-kB inhibitors | 4 SC AG (DE) | 2006-11-02 | — | — | US | disclosed |
| WO-2006032322-A1 | NOVEL HETEROCYCLIC NF-κB INHIBITORS | 4SC AG (DE) | 2006-03-30 | — | — | WO | disclosed |
| US-20060069102-A1 | Novel heterocyclic NF-kB inhibitors | 4 SC AG (DE) | 2006-03-30 | — | — | US | disclosed |
| EP-1637529-A1 | Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof | 4SC AG (DE) | 2006-03-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219190-A1 | Heterocyclic NF-kB Inhibitors | NFKBIA, NFKB2, NFRKB | AOC3 1567/4885BAZ2A 1435/4885GSK3B 908/4885 |
| US-20060247253-A1 | Novel heterocyclic NF-kB inhibitors | NFKBIA, NFRKB, NFKB2 | AOC3 524/4885BAZ2A 778/4885GSK3B 1729/4885 |
| US-20120022068-A1 | NOVEL HETEROCYCLIC NF-kB INHIBITORS | NFKB2, NFKBIA, NFRKB | AOC3 1825/4885BAZ2A 337/4885GSK3B 1735/4885 |
| US-20060069102-A1 | Novel heterocyclic NF-kB inhibitors | NFKBIA, NFKB2, NFRKB | AOC3 1312/4885BAZ2A 1676/4885GSK3B 1642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.