Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | TTK | P33981 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2566770 | 0.79 | NPC1 (0.65) | MEN1KMT2AROCK2ROCK1RAB9A | |
| SCHEMBL5411112 | 0.77 | P2RX7 (0.65) | MEN1KMT2AROCK2ROCK1RAB9A | |
| SCHEMBL2557544 | 0.77 | TTK (0.63) | MEN1KMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4577230 | 0.77 | ROCK2 (0.67) | MEN1KMT2AROCK2ROCK1RAB9A | |
| SCHEMBL17776529 | 0.77 | ROCK2 (0.71) | MEN1KMT2AROCK2ROCK1RAB9A | |
| SCHEMBL17594115 | 0.76 | MEN1 (0.67) | MEN1KMT2AROCK2ROCK1RAB9A | |
| SCHEMBL2571077 | 0.76 | ROCK2 (0.74) | MEN1KMT2AROCK2ROCK1RAB9A | |
| SCHEMBL5413020 | 0.76 | ROCK2 (0.65) | MEN1KMT2AROCK2ROCK1RAB9A | |
| SCHEMBL29099834 | 0.75 | ROCK2 (0.66) | MEN1KMT2AROCK2ROCK1RAB9A | |
| SCHEMBL1457310 | 0.75 | MEN1 (0.66) | MEN1KMT2AROCK2ROCK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |