⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681942 | 0.83 | ALDH1A1 (0.54) | — | |
| SCHEMBL2689421 | 0.80 | CYP1A2 (0.43) | — | |
| SCHEMBL5713265 | 0.77 | — | — | |
| SCHEMBL1659398 | 0.76 | — | — | |
| SCHEMBL28945842 | 0.75 | LMNA (0.36) | — | |
| SCHEMBL25293741 | 0.74 | — | — | |
| SCHEMBL12203096 | 0.74 | — | — | |
| SCHEMBL625309 | 0.74 | — | — | |
| SCHEMBL2612028 | 0.74 | — | — | |
| SCHEMBL5265368 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3409658-B9 | TETRAHYDRONAPHTHALENE DERIVATIVE | ONO PHARMACEUTICAL CO (JP) | 2024-07-17 | — | — | EP | disclosed |
| EP-3409658-B1 | TETRAHYDRONAPHTHALENE DERIVATIVE | ONO PHARMACEUTICAL CO (JP) | 2024-03-06 | — | — | EP | disclosed |
| CN-115667243-A | Tetrahydroisoquinoline compounds as NRF2 activators | 希四克斯探索有限公司 | 2023-01-31 | — | — | CN | disclosed |
| WO-2021074279-A1 | SPIRO-FUSED TRICYCLIC MAP4K1 INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2021-04-22 | — | — | WO | disclosed |
| US-10730830-B2 | Tetrahydronaphthalene derivative | ONO PHARMACEUTICAL CO., LTD. (JP) | 2020-08-04 | — | — | US | disclosed |
| US-20190031605-A1 | TETRAHYDRONAPHTHALENE DERIVATIVE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2019-01-31 | — | — | US | disclosed |
| EP-3409658-A1 | TETRAHYDRONAPHTHALENE DERIVATIVE | ONO Pharmaceutical Co., Ltd. (JP) | 2018-12-05 | — | — | EP | disclosed |
| EP-2552892-A1 | EFFICIENT SYNTHESIS FOR THE PREPARATION OF MONTELUKAST AND NOVEL CRYSTALLINE FORM OF INTERMEDIATES THEREIN | KRKA, D.D., Novo Mesto (SI) | 2013-02-06 | — | — | EP | disclosed |
| WO-2011121091-A1 | EFFICIENT SYNTHESIS FOR THE PREPARATION OF MONTELUKAST AND NOVEL CRYSTALLINE FORM OF INTERMEDIATES THEREIN | KRKA, D.D., NOVO MESTO (SI) | 2011-10-06 | — | — | WO | disclosed |
| WO-2008098965-A1 | PROCESS FOR OBTAINING MONTELUKAST | INKE, S.A. (ES) | 2008-08-21 | — | — | WO | disclosed |
| EP-1958936-A1 | Process for obtaining montelukast | INKE, S.A. (ES) | 2008-08-20 | — | — | EP | disclosed |
| US-20080194825-A1 | PROCESS FOR OBTAINING MONTELUKAST | INKE, S.A. (ES) | 2008-08-14 | — | — | US | disclosed |
| CN-1420113-A | Method for preparing Menglusitena and intermediate preparation thereof | SHANGDI XINSHIJI BIO MEDICAL I (CN) | 2003-05-28 | — | — | CN | disclosed |