Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 4/20 | 0.47 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | MGAM | O43451 | 3/20 | 0.40 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | SI | P14410 | 3/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562891 | 0.92 | KEAP1 (0.47) | KEAP1SLC9A1HCAR3RAB9ANPC1 | |
| SCHEMBL19848287 | 0.86 | KEAP1 (0.47) | KEAP1SLC9A1HCAR3RAB9ANPC1 | |
| SCHEMBL8221347 | 0.84 | RAB9A (0.51) | KEAP1SLC9A1HCAR3RAB9ANPC1 | |
| SCHEMBL7854822 | 0.80 | KEAP1 (0.39) | KEAP1SLC9A1HCAR3RAB9ANPC1 | |
| SCHEMBL3285969 | 0.79 | MGAM (0.42) | KEAP1RAB9ANPC1MGAMAMY1A | |
| SCHEMBL25221496 | 0.79 | KEAP1 (0.41) | KEAP1SLC9A1HCAR3RAB9ANPC1 | |
| SCHEMBL31473739 | 0.78 | KEAP1 (0.44) | KEAP1SLC9A1HCAR3RAB9ANPC1 | |
| SCHEMBL27037689 | 0.78 | KEAP1 (0.44) | KEAP1SLC9A1HCAR3RAB9ANPC1 | |
| SCHEMBL18912134 | 0.77 | KEAP1 (0.42) | KEAP1SLC9A1HCAR3RAB9ANPC1 | |
| SCHEMBL6268160 | 0.77 | MGAM (0.43) | KEAP1MGAMAMY1AGAASI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023087027-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-05-19 | — | — | WO | disclosed |