Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.44 |
| ▸ | TERT | O14746 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 7/20 | 0.43 |
| ▸ | RAB9A | P51151 | 7/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8221347 | 0.84 | RAB9A (0.51) | NPC1RAB9AKEAP1SLC9A1HCAR3 | |
| SCHEMBL25221496 | 0.79 | KEAP1 (0.41) | NPC1RAB9AKEAP1SLC9A1HCAR3 | |
| SCHEMBL27037689 | 0.78 | KEAP1 (0.44) | NPC1RAB9AKEAP1SLC9A1HCAR3 | |
| SCHEMBL31473739 | 0.78 | KEAP1 (0.44) | NPC1RAB9AKEAP1SLC9A1HCAR3 | |
| SCHEMBL31475782 | 0.77 | RAB9A (0.47) | NPC1RAB9AKEAP1SLC9A1HCAR3 | |
| SCHEMBL8562891 | 0.77 | KEAP1 (0.47) | NPC1RAB9AKEAP1SLC9A1HCAR3 | |
| SCHEMBL12121754 | 0.77 | RAB9A (0.43) | NPC1RAB9AKEAP1SLC9A1HCAR3 | |
| SCHEMBL33526481 | 0.74 | KEAP1 (0.47) | NPC1RAB9AKEAP1SLC9A1HCAR3 | |
| SCHEMBL19848322 | 0.74 | KEAP1 (0.47) | NPC1RAB9AKEAP1SLC9A1HCAR3 | |
| SCHEMBL18912134 | 0.73 | KEAP1 (0.42) | NPC1RAB9AKEAP1SLC9A1HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023215494-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-11-09 | — | — | WO | disclosed |
| WO-2023087027-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-05-19 | — | — | WO | disclosed |
| CN-1761787-A | Oxidation system comprising macrocyclic metal complexes, method for the production and use thereof | LANXESS B V (NL) | 2006-04-19 | — | — | CN | disclosed |