SCHEMBL2556006

SCHEMBL2556006

O=Cc1c(-c2ccc(F)c(F)c2)[nH]c2c(Cl)cccc12

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.38
KDM4E B2RXH2 2/20 0.38
HPGD P15428 2/20 0.38
MEN1 O00255 1/20 0.38
ALDH1A1 P00352 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
NPC1 O15118 1/20 0.38
HCRTR1 O43613 1/20 0.38
MAPT P10636 1/20 0.38
RAB9A P51151 1/20 0.38
DYRK1A Q13627 2/20 0.37
PDE7A Q13946 1/20 0.37
FASN P49327 1/20 0.36
AHR P35869 1/20 0.36
HTR2A P28223 1/20 0.35
HTR2C P28335 1/20 0.35
KCNH2 Q12809 1/20 0.35
TNF P01375 1/20 0.35
TUBB4A P04350 2/20 0.34
TUBB P07437 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2558215 0.88 CNR1 (0.37) HTR2AHTR2CKCNH2TUBB4ATUBB
SCHEMBL15331117 0.85 DYRK1A (0.41) KMT2AKDM4EHPGDMEN1ALDH1A1
SCHEMBL15330074 0.85 DYRK1A (0.43) KMT2AKDM4EMEN1ALDH1A1TDP1
SCHEMBL15329357 0.85 DYRK1A (0.43) KMT2AMEN1ALDH1A1TDP1DYRK1A
SCHEMBL2555678 0.85 KMT2A (0.41) KMT2AKDM4EHPGDMEN1ALDH1A1
SCHEMBL15331721 0.85 DYRK1A (0.44) KMT2AMEN1ALDH1A1TDP1DYRK1A
SCHEMBL2560117 0.84 KDM4E (0.39) KMT2AKDM4EALDH1A1MAPTPDE7A
SCHEMBL15330372 0.84 CNR1 (0.38) KMT2AKDM4EHPGDNPC1HCRTR1
SCHEMBL2556873 0.81 ALDH1A1 (0.50) KMT2AKDM4EHPGDMEN1ALDH1A1
SCHEMBL15331556 0.81 PTGS2 (0.37) KDM4EALDH1A1MAPTPDE7AAHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed