Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 9/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12518001 | 0.89 | MET (0.45) | METPDE10APPARGPPARA | |
| SCHEMBL12516728 | 0.89 | TTK (0.39) | METFGFR3KDRHSD17B13PPARG | |
| SCHEMBL13274725 | 0.89 | MET (0.34) | METFGFR3KDRHSD17B13PPARG | |
| SCHEMBL256018 | 0.89 | TP53 (0.35) | TP53CYP3A4METCSNK1DDHFR | |
| SCHEMBL2222009 | 0.89 | MET (0.43) | TP53METCSNK1DFGFR3KDR | |
| SCHEMBL12516348 | 0.88 | MET (0.36) | METDHFRFGFR3KDRHSD17B13 | |
| SCHEMBL13274895 | 0.86 | MET (0.44) | MET | |
| SCHEMBL13274873 | 0.86 | MET (0.43) | METFGFR3KDRHSD17B13 | |
| SCHEMBL2221788 | 0.85 | MET (0.34) | METFGFR3KDRHSD17B13 | |
| SCHEMBL2224454 | 0.85 | FYN (0.38) | CYP3A4METFGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012030633-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-03-08 | — | — | WO | disclosed |