Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 8/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | NQO2 | P16083 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL255607 | 0.89 | TP53 (0.35) | TP53CYP3A4DHFRMETCSNK1D | |
| SCHEMBL163957 | 0.86 | MET (0.43) | METNQO2 | |
| SCHEMBL173429 | 0.84 | BRD4 (0.34) | METPPARGPPARANQO2 | |
| SCHEMBL12516728 | 0.80 | TTK (0.39) | METFGFR3KDRMEN1NPC1 | |
| SCHEMBL12518001 | 0.79 | MET (0.45) | METPPARGPPARA | |
| SCHEMBL2222009 | 0.78 | MET (0.43) | TP53METCSNK1DFGFR3KDR | |
| SCHEMBL13274725 | 0.78 | MET (0.34) | METFGFR3KDRNPC1PPARG | |
| SCHEMBL12516348 | 0.77 | MET (0.36) | DHFRMETFGFR3KDR | |
| SCHEMBL2224454 | 0.76 | FYN (0.38) | CYP3A4METFGFR3KDRNPC1 | |
| SCHEMBL164341 | 0.76 | MET (0.38) | METFGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012030633-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-03-08 | — | — | WO | disclosed |